клеток
единичных
биологии
лаборатория
заведующий кафедрой
Денисов Евгений Владимирович
Доктор биологических наук
Направления
деятельности
02
Молекулярный атлас сарком мягких тканей
01
Молекулярный атлас злокачественных лимфопролиферативных заболеваний детского возраста
Компетенции
Полногеномное, полноэкзомное, полнотранскриптомное, бисульфитное и таргетное секвенирование
Секвенирование ДНК единичных клеток
Секвенирование РНК единичных клеток
Пространственная транскриптомика
Биоинформатический анализ
проекты
Современные молекулярно-генетические технологии для разработки новых алгоритмов персонализации терапии сарком мягких тканей
РНФ 23-65-00003
Томский национальный исследовательский медицинский центр РАН
коллаборации
НМИЦ онкологии им. Н.Н. Блохина
Институт системного программирования им. В.П. Иванникова РАН
НМИЦ ДГОИ им. Дмитрия Рогачева
Публикации
Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets
Menyailo M.E., Kopantseva E.E., Khozyainova A.A., Korobeynikova A.A., Denisov E.V. Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets. Cancer Gene Therapy 2024. DOI: 10.1038/s41417-024-00856-7
GLOW Consortium. International Prognostic Score for Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Binkley M.S., Flerlage J.E., Savage K.J., Akhtar S., Steiner R., Zhang X.Y., Dickinson M., Prica A., Major A., Hendrickson P.G., Hopkins D., Ng A., Casulo C., Baron J., Roberts K.B., Al Kendi J., Balogh A., Ricardi U., Torka P., Specht L., … GLOW Consortium. International Prognostic Score for Nodular Lymphocyte-Predominant Hodgkin Lymphoma. Journal of Clinical Oncology 2024;42(19):2271-2280. DOI: 10.1200/JCO.23.01655
Decoding Chemotherapy Resistance of Undifferentiated Pleomorphic Sarcoma at the Single Cell Resolution: A Case Report
Fetisov T.I., Menyailo M.E., Ikonnikov A.V., Khozyainova A.A., Tararykova A.A., Kopantseva E.E., Korobeynikova A.A., Senchenko M.A., Bokova U.A., Kirsanov K.I., Yakubovskaya M.G., Denisov E.V. Decoding Chemotherapy Resistance of Undifferentiated Pleomorphic Sarcoma at the Single Cell Resolution: A Case Report. Journal of Clinical Medicine 2024;13:7176. DOI: 10.3390/jcm13237176
TP53 variants underlying pediatric low-hypodiploidy B-cell acute lymphoblastic leukemia demonstrate diverse origins and may persist as a hematopoietic clone in remission
Itov A., Ilyasova K., Soldatkina O., Kazakova A., Kozeev V., Semchenkova A., Osipova E., Boichenko E., Volchkov E., Popov A., Zerkalenkova E., Roumiantseva J., Novichkova G., Karachunskiy A., Olshanskaya Y. TP53 variants underlying pediatric low-hypodiploidy B-cell acute lymphoblastic leukemia demonstrate diverse origins and may persist as a hematopoietic clone in remission. EJHaem 2024;5(5):1010-1013. DOI: 10.1002/jha2.986
Patysheva M.R., Kolegova E.S., Khozyainova A.A., Prostakishina E.A., Korobeynikov V.Y., Menyailo M.E., Iamshchikov P.S., Loos D.M., Kovalev O.I., Zavyalova M.V., Fedorova I.K., Kulbakin D.E., Larionova I.V., Polyakov A.P., Yakovleva L.P., Kropotov M.A., Sukortseva N.S., Lu Y., Jia L., Arora R., Choinzonov E.L., Bose P., Denisov E.V. Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics. Scientific Reports 2024;14:26255. DOI: 10.1038/s41598-024-76044-2
Characterization of a Novel Pathogenic PLCG2 Variant Leading to APLAID Syndrome Responsive to a TNF Inhibitor
Yang Z., Tao P., Han X., Kozlova A., He T., Volchkov E., Nesterenko Z., Pershin D., Raykina E., Fatkhudinov T., Korobeynikova A., Aksentijevich I., Yang J., Shcherbina A., Zhou Q., Yu X. Characterization of a Novel Pathogenic PLCG2 Variant Leading to APLAID Syndrome Responsive to a TNF Inhibitor. Arthritis & Rheumatology 2024;76(11):1670-1678. DOI: 10.1002/art.42948
Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer
Gerashchenko T., Skitchenko R., Korobeynikova A., Kuanysheva K., Khozyainova A., Vorobiev R., Rodionov E., Miller S., Topolnitsky E., Shefer N., Anisimenko M., Zhuikova L., Vashisth M., Pankova O., Perelmuter V., Rezapova V., Artomov M., Denisov E. Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer. Gene 2024;920:148507. DOI: 10.1016/j.gene.2024.148507
Potential value of high-throughput single-cell DNA sequencing of Juvenile myelomonocytic leukemia: report of two cases
Volchkov E.V., Khozyainova A.A., Gurzhikhanova M.K., Larionova I.V., Matveev V.E., Evseev D.A., Ignatova A.K., Menyailo M.E., Venyov D.A., Vorobev R.S., Semchenkova A.A., Olshanskaya Yu.V., Denisov E.V., Maschan M.A. Potential value of high-throughput single-cell DNA sequencing of Juvenile myelomonocytic leukemia: report of two cases. npj Systems Biology and Applications 2023;9:41. DOI: 10.1038/s41540-023-00303-7
Comparison of the Illumina NextSeq 2000 and GeneMind Genolab M sequencing platforms for spatial transcriptomics
Iamshchikov P., Larionova I., Gerashchenko T., Piankov D., Koshkin P., Korostelev S., Denisov E. Comparison of the Illumina NextSeq 2000 and GeneMind Genolab M sequencing platforms for spatial transcriptomics. BMC Genomics 2023;24:102. DOI: 10.1186/s12864-023-09192-w
How to catch metastatic seeds. Biochimica et Biophysica Acta (BBA)
Gerashchenko T.S., Schegoleva A.A., Khozyainova A.A., Choinzonov E.L., Denisov E.V. Metastasis prevention: How to catch metastatic seeds. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2023;1878(3):188867. DOI: 10.1016/j.bbcan.2023.188867